Patch with laboratory vessels “repairs” hearts



Heart disease is the leading cause of death worldwide. When a person has a myocardial infarction, the blocked artery leads to oxygen deprivation in the heart area and eventually to massive cardiac cell death, vascular damage and inflammation. ACS Biomaterials Science & Engineering ┬╗that they developed a patch that bears tiny laboratory blood vessels and which, as seen in experiments on rats and pigs, led to improved recovery after myocardial infarction. Previous efforts to repair the heart after a myocardial infarction require regeneration of damaged heart muscle tissue as well as the creation of new blood vessels to restore the supply of oxygen and nutrients to the cells. Researchers have tried to develop curative therapies for However, to date, in most cases, their formation was extremely complex or the patches did not restore both the lost heart muscle tissue and the blood supply to the affected area. The “artificial” patch’s Ke Cheng, Professor of Regenerative Medicine at the State University of North Carolina and colleagues have developed a laboratory-made cardiac patch that is housed in a special fibrous gel along with stromal heart cells. When this patch was implanted in rats that had suffered a myocardial infarction, the cells it carried secreted growth factors that led to regeneration of the heart muscle and blood vessels in the area. The patch has now been further tested in rats as well as in pigs which have a cardiovascular system that looks more like a human than a rodent. Improvement of a number of indicators As new experiments have shown in rats who have had a myocardial infarction, those of them who received the patch showed four weeks after placement of less scar tissue, increased healthy heart muscle tissue as well as improved cardiac muscle capacity. with rats that did not receive the patch. The results were similar in pigs. According to the results, the placement of the patch increased the “recruitment” of progenitor cells in the damaged area as well as the development of new blood vessels while reducing cell death and suppressing inflammation. The first Although previous studies have used precursor cells of blood vessels or natural blood vessels to create heart patches, the study by experts from North Carolina State University is the first to prove the success of a patch that carries artificial blood vessels in the repair of myocardial infarction in a large animal model. However, the researchers note that further studies are needed on the safety and effectiveness of this technology before it is applied to humans. Follow it on Google News and be the first to know all the news. See all the latest news from Greece and the world, at



Source link

Leave a Reply

Your email address will not be published. Required fields are marked *