How coronavirus destroys the lungs and causes chronic disease

Examination of the tissues of patients who have died from COVID-19 sheds light on the damage that the new coronavirus causes to the lungs and provides an answer to why many people develop long-term symptoms. Unique features Was conducted by researchers at King’s College London in collaboration with colleagues from the University of Trieste and the International Center for Genetic Engineering and Biology in Italy and reveals those unique characteristics of the SARS-CoV-2 virus that make it so “persistent” and strong, able to afflict people who are affected even for many months. Some patients with COVID-19 experience symptoms such as loss of smell and taste as well as extensive thrombosis. In fact, some may experience the effects of the disease, such as intense tiredness and shortness of breath, for months – these are the so-called “long-term patients”. To date, a limited number of studies have been performed based on necropsies of patients with COVID-19, which proves that the effects of the disease on different organs remain largely unknown. COVID-19 at the University Hospital of Trieste from February to April 2020. The research team took samples from the lungs, heart, liver and kidneys to look at the behavior of the virus. In some cases, there was extensive lung damage, with the main features being severe structural damage and the conversion of normal tissue to fibrous. Abnormally large cells. In addition, approximately 90% of patients had two additional COVID-19 compared to other forms of pneumonia. At first, patients developed extensive thrombi in the arteries and veins of the lungs. Second, several lung cells were abnormally large and had many nuclei – this was due to the fusion of different cells that formed large cells. These cell formations (syncytia) were created due to the presence of the spike protein located on the surface of the new coronavirus and which the virus uses to enter human cells. When the protein was present on the surface of cells infected with SARS-CoV-2, it caused it to fuse with other normal lung cells, eventually leading to inflammation and thrombosis. Prolonged structural changes. in the cells of the respiratory tract as well as in the epithelial cells of the blood vessels, in combination with the conjunctiva cells. The presence of these long-lived infected cells is thought to be responsible for the large structural changes observed in the lungs that may persist for weeks or even months, providing an explanation for the onset of COVID-19 duration. However, the study did not show prolonged inflammation in other organs. According to Professor Mauro Jiaka of the British Heart Foundation at King’s College London, “the new findings are fascinating. “COVID-19 is not just a disease caused by the death of infected cells, but it is probably the result of these abnormal cells that build up in the lungs and stay in them for long periods of time.” Search for drugs that block spike proteinThe research team is now studying the effect of these abnormal cells that form in the lungs on thrombosis and inflammation and is looking for new drugs that will block the spike protein that is responsible for the virus. Follow it on Google News and be the first to know all the news See all the latest News from Greece and the World, at

Source link

Leave a Reply

Your email address will not be published. Required fields are marked *