Genetic lesions in CRISPR-modified embryos

An American experiment aimed at correcting genetic diseases in human embryos shows that the revolutionary CRISPR technique often has serious side effects – a finding that justifies scientists who consider it premature to be used in humans. caused the change, such as the loss of an entire chromosome or large portions of it. The study is published in the prestigious journal Cell. The researchers used the CRISPR technique (pronounced “crisper”), which was applied in 2018 by a Chinese scientist to create first-order babies. The Chinese researcher ended up in prison and became the target of international criticism, as most of the scientific community considers it premature to use CRISPR for embryo modification. high productivity. His discovery was awarded the Nobel Prize in Chemistry this year. The technique can also be used in genetic therapies. However, its use in human sperm, ova or embryos remains controversial, as genetic changes are passed on to future generations, without fully knowing all the possible side effects. “If our results were known two years ago, I doubt it would have been. “Apply to embryos,” Dieter Ogley, lead author of a new study at Columbia University, told the Associated Press. “Unexpected results in the laboratory. causes blindness. The goal was to correct the mutation. In some embryos, the CRISPR technique was applied during fertilization, which is considered the best time for such efforts. Other embryos were modified at the two cell stage. Cells from the embryos were examined at various stages of development to assess how many of them had the mutation corrected. The researchers report that, contrary to expectations, the technique did not work in any of the embryos that were modified during fertilization. It seemed to have an effect on only 3 of the 45 embryos that were later modified. Of the remaining 42 embryos, most had lost an entire chromosome, making the embryos unviable. “We found that instead of correcting the mutation, the chromosome carrying the mutation disappears,” Igley said. Researchers now warn that using CRISPR to correct genetic abnormalities in fetuses can lead to serious side effects and need further study before being used in clinical practice. treat diseases due to excess chromosome copies, such as Down syndrome. Follow it on Google News and be the first to know all the news. See all the latest news from Greece and the world, at

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