Coronavirus: Children produce weaker antibodies because they “clean” it more easily



Children and adults produce different types and different amounts of antibodies to the SARS-CoV-2 coronavirus, according to a new US scientific study. The differences reflect the fact that the course of Covid-19 infection varies with age, as most children easily “clear” the virus from their body (it is still unknown why this happens), resulting in the development of weaker antibodies. Researchers at Columbia University College of Medicine in New York, led by Professor of Microbiology-Immunology Donna Farber, published in the journal Immunology, studied 47 children aged three to 11 years 32 adults with Covid-19, who had mild to severe symptoms. “Children were found to produce antibodies that had a different ‘profile’ than adults. ‘Our study provides an in-depth examination of antibodies to SARS-CoV-2 in children and reveals a strong contrast with adults,'” Farber said. . “In children, the course of the infection is much shorter and probably not as widespread in the body as in adults. “Children can clear the virus more efficiently than adults, so they do not need a strong immune response with antibodies to get rid of it,” said Mateo Poroto, an associate professor at Columbia School of Pediatrics. In a new comparative study, children produce fewer IgG antibodies that recognize the virus’ protruding spike protein that infects human cells. Also, children’s antibodies have little neutralizing ability, while all adults, even those between 20-30 years old, produce several neutralizing antibodies, which is more pronounced in those with more severe Covid-19. produce more neutralizing antibodies, this, according to Farber, has to do with the fact that the coronavirus is in their body for longer. “There is a link between the size of the immune response and the size of the infection,” he said. The more severe the infection, the stronger the immune response, because the patient needs more cells of the immune system and more immune response to clear a higher dose of the pathogenic virus. “On the contrary, according to Farber, it does not kill many of their cells. ” “Because children clear the virus quickly, they do not have a widespread infection and they do not need a strong immune response,” Poroto added. inside. The immune system would see this protein and develop antibodies against it only if the virus was very widespread in the body, which is obviously not the case in children. However, many antibody tests “target” precisely antibodies to this N protein, so they may be falsely negative in many children, even though they were previously infected with the coronavirus. for less time than adults, so they are less likely to transmit the coronavirus. “Current studies in other countries show that younger school-age children are not carriers of the new virus, and our evidence supports this,” Farber said. that they will have a similarly weak response to a future vaccine. “Although children do not produce neutralizing antibodies in response to a natural infection from SARS-CoV-2, vaccines are designed to elicit a protective immune response without infection. Children respond very well to vaccines and I think they will develop good neutralizing antibodies after a new coronavirus vaccine. “They will probably be better protected than adults,” Farber said, adding that so far very few vaccine trials have involved children. final conclusions, including on how different the immune response of children at different ages. Source: APE-BEA Follow it on Google News and find out all the news first See all the latest News from Greece and the World, at



Source link

Leave a Reply

Your email address will not be published. Required fields are marked *