Common mutation behind “overnight syndrome”

Do you sleep early? Do you always have to apologize to your boss for being late in the morning? You can now invoke a new excuse: it’s not your fault, but the overnight gene. sleep-wake cycles in the course of 24 hours, also known as “circadian rhythms”. In addition to sleep, the biological clock affects the entire metabolism, triggering diurnal fluctuations in the activity of a variety of genes. An important breakthrough for patients with sleep disorders came in 2017, when the team of Nobel laureate Michael Young at Rockefeller University US spotted a mutation that increases the duration of the biological daily cycle by more than 24 hours. Acceleration, deceleration. Extending the cycle has been found to cause significant changes: Other, rarer mutations have been found to shorten the life cycle, and carriers tend to sleep “with chickens.” The new study, published in the online journal PNAS, now sheds new light on its discovery. 2017 revealing the mechanism of the phenomenon. The overnight mutation concerns the gene of “cryptochrome”, a of the four basic proteins of the biological clock. Two of these proteins (CLOCK and BMAL1) bind to a complex that activates the cryptochrome genes and a fourth protein. These genes gradually block the action of the first two proteins, so gradually both cease to function (express) and the cycle begins from the beginning. This feedback loop is the central mechanism of the biological clock. A new study shows that a piece is missing from the cryptochrome mutant protein. The lack of this section affects the interaction of the cryptocurrency with the other three proteins of the clock in a way that prolongs the cycle by more than 24 hours. identify molecules that will restore the normal action of cryptochrome. However, this is not expected soon. Until a cure is found, the overnight carriers of the mutation will continue to suffer from the alarm clock. Follow it on Google News and be the first to know all the news. See all the latest news from Greece and the world, at

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